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The WHO Covid-19 Research Database is a resource created in response to the Public Health Emergency of International Concern (PHEIC). Its content remains searchable and spans the time period March 2020 to June 2023. Since June 2023, manual updates to the database have been discontinued.

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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.

Okba, Nisreen M A; Widjaja, Ivy; Li, Wentao; GeurtsvanKessel, Corine H; Farag, Elmoubasher A B A; Al-Hajri, Mohammed; Park, Wan Beom; Oh, Myoung-Don; Reusken, Chantal B E M; Koopmans, Marion P G; Bosch, Berend-Jan; Haagmans, Bart L.

Emerg Infect Dis ; 26(5): 1024-1027, 2020 May.

Article in English | MEDLINE | ID: covidwho-5763

ABSTRACT

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

Subject(s)

Antibodies, Viral/blood , Coronavirus Infections/diagnosis , Enzyme-Linked Immunosorbent Assay/methods , Immunoassay/methods , Middle East Respiratory Syndrome Coronavirus/immunology , Serologic Tests/methods , Antibodies, Neutralizing/blood , Coronavirus Infections/blood , Coronavirus Infections/immunology , Coronavirus Infections/virology , Humans , Species Specificity

ABSTRACT

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